Description

Sygnature Discovery (Nottingham, UK) has been using an Asynt DrySyn SnowStorm system to perform low temperature reactions which have traditionally been difficult  to undertake reproducibly on a small to medium scale.

The Asynt DrySyn SnowStorm offers an attractive solution to laboratories undertaking low temperature reaction chemistries. Available in a choice of configurations, the DrySyn SnowStorm system provides controlled cooling and heating for sub-ambient parallel chemistry without the need for jacketed reaction vessels, or ice baths. Operating with a suitable chiller / circulator, a DrySyn SnowStorm system provides accurate, stable temperature control down to -50 °C and up to +150 °C.

Dr Geraint Jones, Associate Director of Chemistry at Sygnature Discovery commented, "Being able to maintain a sub-ambient temperature sometimes for significant periods is really important for reaction reproducibility. The DrySyn SnowStorm connects to an external chiller unit and holds temperatures at a set-point for as long as is required. Setting temperature ramping profiles is also possible which is important in optimisation studies and is a real added benefit to us"

His colleague Mark Mills, Senior Research Chemist at Sygnature Discovery added, "We purchased the DrySyn SnowStorm to achieve tight temperature control (at -20°C) for a reaction involving a stereoselective cyclisation. If we had not been able to maintain this temperature for a sustained period, racemisation could have occurred. We selected this Asynt equipment because it integrated well into our way of working and allowed the use of round-bottomed flasks in a variety of sizes, thereby providing the flexibility to conduct small to medium scale reactions".