logo
logo
EpiMark® Bisulfite Conversion Kit

EpiMark® Bisulfite Conversion Kit


Genomic DNA from many organisms has modified nucleotides. In the mammalian genome, the modified base is predominately 5-methylcytosine (5-mC), which is involved in gene expression regulation, including selective inactivation of one X chromosome in females of mammalian species (1,2). Symmetrical CpG DNA methylation is heritable, but also reversible. This change of methylation status results in an enormous number of combinations of epigenetic states that can regulate gene expression.

In mammalian cells, DNA methylation mainly occurs in CpG dinucleotides and is carried out by two methyltransferase enzymatic activities, namely, maintenance methylation and de novo methylation.

The maintenance methyltransferase, DNMT1, is involved in the DNA methylation after every cellular DNA replication cycle. DNMT3a and DNMT3b are the de novo methyltransferases that are active in early development.

Prices direct from New England Biolabs, Inc.

Quick response times

Exclusive Labsave savings/discounts

Latest promotions

BaySpec, Inc. is offering special academic discount with the new NomadicTM multi-excitation confocal Raman microscope. NomadicTM is the only Raman microscope...

15% off on BMT Incubators - Climacell, Friocell, Incucell / Incucell V. On-Line Special 15% Discount on all Incubators, including Incubator options. •...

Order any Aries FilterWorks High Purity Lab Water Purification System an receive the first Years’ worth of Carbon and/or DI filters free! Please...

Combination Really-Flow™ Fluoride electrode, Epoxy body, Single Junction, Refillable with 1 meter low-noise cable and BNC connector. Weiss...

Avoid the risks associated with sample transfer and reduce hands-on time when you bind, wash, elute and/or concentrate your protein in the all-in-one...

Use promo code EASY3 to receive 13% off and FREE shipping!Experience a new dimension of electronic pipetting with the NEW Easypet 3 pipette controller. The...

Jenway’s 73 series spectrophotometer range provides four models with a narrow spectral bandwidth of 5nm and an absorbance range of –0.3 to 2.5A,...